Cushing Sendromu Nedir : S\u0131k ad\u0131 ge\u00e7en bu hastal\u0131k b\u00f6brek\u00fcst\u00fc bezinin bir hastal\u0131\u011f\u0131d\u0131r. B\u00f6brek\u00fcst\u00fc bezi hayati \u00f6nemi olan hormonlar\u0131 salg\u0131layan bir endokrin organd\u0131r. Ad\u0131n\u0131 bulundu\u011fu yerden al\u0131r. B\u00f6breklerimizin \u00fcst\u00fcnde yer almas\u0131na ra\u011fmen b\u00f6breklerle ilgisi yoktur. Korteks dedi\u011fimiz d\u0131\u015f k\u0131sm\u0131 \u00fc\u00e7 b\u00f6l\u00fcmden olu\u015fur, i\u00e7 k\u0131sm\u0131 ise tek b\u00f6l\u00fcmd\u00fcr. Korteks de v\u00fccut i\u00e7in gerekli kortizon yap\u0131s\u0131ndaki Hormonlar \u00fcretilir.<\/p>\n
Bu hormonlar \u00fc\u00e7 gruptur: <\/p>\n
seks steroid hormonlar\u0131mineralokortikoidlerglukokortikoidler<\/p>\n
Cushing sendromu, b\u00f6brek\u00fcst\u00fc bezinin korteks olarak adland\u0131r\u0131lan d\u0131\u015f k\u0131sm\u0131n\u0131n fazla \u00e7al\u0131\u015fmas\u0131 sonucu ortaya \u00e7\u0131kar. Hormonal a\u00e7\u0131dan ise kortizol y\u00fcksekli\u011fi durumudur. Yak\u0131nmalar kortizol fazlal\u0131\u011f\u0131n\u0131n t\u00fcm v\u00fccut sistemlerini etkilemesi sonucu ortaya \u00e7\u0131kar. Harvey Cushing taraf\u0131ndan tan\u0131mland\u0131\u011f\u0131 i\u00e7in bu ki\u015fi ile ayn\u0131 ad\u0131 alm\u0131\u015ft\u0131r. Cushing sendromu 30 ile 50 ya\u015flar aras\u0131nda g\u00f6r\u00fcl\u00fcr. kad\u0131nlarda erkeklere g\u00f6re 3- 4 kat daha s\u0131k g\u00f6r\u00fcl\u00fcr. \u00c7ocuklarda ise her iki cinste ayn\u0131 s\u0131kl\u0131kta g\u00f6r\u00fcl\u00fcr.<\/p>\n
Cushing sendromunda yak\u0131nmalar v\u00fccuttaki kortizol Hormon seviyesinin y\u00fcksekli\u011fine ba\u011fl\u0131 olarak geli\u015fir. Kortizol salg\u0131lanmas\u0131 b\u00f6brek\u00fcst\u00fc bezinden olur. B\u00f6brek\u00fcst\u00fc bezinin fazla \u00e7al\u0131\u015fmas\u0131na i\u00e7inde olu\u015fan iyi veya k\u00f6t\u00fc huylu t\u00fcm\u00f6rler, hipofiz bezinden salg\u0131lanan ve b\u00f6brek\u00fcst\u00fc bezinin kortizol salg\u0131lamas\u0131n\u0131 sa\u011flayan Hormonlar\u0131n fazla salg\u0131lanmas\u0131na neden olan t\u00fcm\u00f6rler neden olur. Hipofize bezinin fazla \u00e7al\u0131\u015fmas\u0131na ba\u011fl\u0131 Cushing sendromu, t\u00fcm hastalar\u0131n y\u00fczde 15 ini olu\u015fturur. Bunlar\u0131n d\u0131\u015f\u0131nda bazen \u00e7e\u015fitli hastal\u0131klar\u0131n tedavisinde kullan\u0131lan kortizon yap\u0131s\u0131ndaki ila\u00e7lar\u0131n yanl\u0131\u015f veya fazla kullan\u0131m\u0131 buna yol a\u00e7abilir. Baz\u0131 hastalar\u0131n kendilerinin kortizol yap\u0131s\u0131ndaki ila\u00e7lar\u0131 gere\u011finden fazla kullanmas\u0131 bu yak\u0131nmalara yol a\u00e7ar.<\/p>\n
Cushing Sendromu Belirtileri<\/p>\n
Cushing sendromunda aydede y\u00fcz dedi\u011fimiz y\u00fcz\u00fcn yuvarlakla\u015farak \u015fi\u015fmanlamas\u0131, \u015fi\u015fmanl\u0131k, y\u00fcz\u00fcn k\u0131zarmas\u0131, cinsel isteksizlik,\u00a0 tansiyon y\u00fcksekli\u011fi, k\u0131llanma, adet d\u00fczeni de\u011fi\u015fiklikleri, \u015feker hastal\u0131\u011f\u0131, gizli \u015feker,\u00a0 halsizlik, v\u00fccutta morluklar, kemik erimesi, v\u00fccutta \u00e7atlaklar, v\u00fccutta Su toplanmas\u0131, Depresyon, kalp ve damar hastal\u0131klar\u0131, ba\u015f a\u011fr\u0131s\u0131, ensede ya\u011f birikimine ba\u011fl\u0131 kal\u0131nla\u015fma, sivilceler, kad\u0131nda sa\u00e7 d\u00f6k\u00fclmesi, b\u00f6brek ta\u015f\u0131 olu\u015fumu g\u00f6r\u00fclebilir. G\u00f6zlerde zaman i\u00e7inde katarakt geli\u015febilir. Mide ve barsakta \u00fclser geli\u015fimi s\u0131kt\u0131r. Kemik erimesine ba\u011fl\u0131 k\u0131r\u0131k riski artm\u0131\u015ft\u0131r.<\/p>\n
Cushing Sendromu Tan\u0131s\u0131<\/p>\n
Yukar\u0131daki yak\u0131nmalar oldu\u011funda cushing hastal\u0131\u011f\u0131 akla getirilmelidir ve bu hastal\u0131kla ilgili tetkikler yap\u0131lmal\u0131d\u0131r. Kan kortizol d\u00fczeyi y\u00fcksekli\u011fi doktor taraf\u0131ndan \u00e7e\u015fitli laboratuar testleriyle saptan\u0131r. B\u00f6brek\u00fcst\u00fc bezi veya hipofizde kitle olup olmad\u0131\u011f\u0131 ultrason, bilgisayarl\u0131 tomografi, manyetik rezonans g\u00f6r\u00fcnt\u00fcleme gibi g\u00f6r\u00fcnt\u00fcleme y\u00f6ntemleri ile saptan\u0131r.<\/p>\n
Cushing Sendromu Tedavisi<\/p>\n
Tan\u0131s\u0131 konulduktan sonra sebebine g\u00f6re tedavisi planlan\u0131r. T\u00fcm\u00f6r varsa operasyonla \u00e7\u0131kar\u0131l\u0131r. Hormon salg\u0131lanmas\u0131na neden olan ba\u015fka bir durum varsa bu da tedavi ile normale getirilir. Hasta d\u0131\u015far\u0131dan y\u00fcksek miktarlarda kortizon Hormonu kullan\u0131yorsa bu d\u00fczenli aral\u0131klarla azalt\u0131larak tedavi sa\u011flan\u0131r.<\/p>\n
HAZIRLAYAN: Dr. Pelin T\u00dcT\u00dcNC\u00dcO\u011eLU, Prof. Dr. Mitat BAH\u00c7EC\u0130<\/p>\n","protected":false},"excerpt":{"rendered":"
Cushing Sendromu Nedir : S\u0131k ad\u0131 ge\u00e7en bu hastal\u0131k b\u00f6brek\u00fcst\u00fc bezinin bir hastal\u0131\u011f\u0131d\u0131r. B\u00f6brek\u00fcst\u00fc bezi hayati \u00f6nemi olan hormonlar\u0131 salg\u0131layan bir endokrin organd\u0131r. Ad\u0131n\u0131 bulundu\u011fu yerden al\u0131r. B\u00f6breklerimizin \u00fcst\u00fcnde yer almas\u0131na ra\u011fmen b\u00f6breklerle ilgisi yoktur. Korteks dedi\u011fimiz d\u0131\u015f k\u0131sm\u0131 \u00fc\u00e7 b\u00f6l\u00fcmden olu\u015fur, i\u00e7 k\u0131sm\u0131 ise tek b\u00f6l\u00fcmd\u00fcr. Korteks de v\u00fccut i\u00e7in gerekli kortizon yap\u0131s\u0131ndaki Hormonlar \u00fcretilir. Bu hormonlar \u00fc\u00e7 gruptur:[Devam\u0131n\u0131 Oku…]<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[22524],"tags":[22975],"_links":{"self":[{"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/posts\/13167"}],"collection":[{"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/comments?post=13167"}],"version-history":[{"count":0,"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/posts\/13167\/revisions"}],"wp:attachment":[{"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/media?parent=13167"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/categories?post=13167"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/tags?post=13167"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}