\u0130mmunolojik mekanizmalarla olu\u015fan ilaca ba\u011fl\u0131 n\u00f6tropenilerin en a\u011f\u0131r \u015fekli agran\u00fclositozdur. \u0130leri derecede n\u00f6tropeni, y\u00fcksek ate\u015f, nekrozlu anjinle seyreden ve yayg\u0131n enfeksiyonla(sepsis) sonlanan bir hastal\u0131kt\u0131r. \u00c7e\u015fitli ila\u00e7lar(epilepsi ila\u00e7lar\u0131, tiroid ila\u00e7ar\u0131, baz\u0131 sakinle\u015ftirici ila\u00e7lar gibi) sebep olabilir. \u0130la\u00e7lar farkl\u0131 \u015fekillerde agran\u00fclositoz meydana getirebilir. Bunlardan biri ila\u00e7lar\u0131n veya onun y\u0131k\u0131m\u0131 s\u0131ras\u0131nda olu\u015fan \u00fcr\u00fcnlerin do\u011frudan kemik ili\u011fi ortam\u0131n\u0131 veya Akyuvar \u00f6nc\u00fcl h\u00fccrelerine zarar vermesidir. Bu olayda genetik e\u011filim de etkili olabilir. \u0130laca ba\u011fl\u0131 agran\u00fclositoz geli\u015fme s\u00fcresi olu\u015fma \u015fekline g\u00f6re de\u011fi\u015fir.\u00a0<\/p>\n
BEL\u0130RT\u0130LER<\/p>\n
Klinik tablo\u00a0\u00a0 asemptomatik olabilece\u011fi gibi ani ate\u015f ve bo\u011faz a\u011fr\u0131s\u0131 ile de kendini g\u00f6sterebilir. Herhangi bir organ\u0131n s\u00fcratle ilerleyen enfeksiyonu \u015feklinde h\u0131zl\u0131 ba\u015flar. Ba\u015flang\u0131\u00e7 belirtileri(semptomlar\u0131) titreme, y\u00fcksek ate\u015f ve bo\u011faz a\u011fr\u0131s\u0131d\u0131r. Ki\u015finin genel durumu h\u0131zla bozulur. Bademcik, yumu\u015fak damak, farinks, di\u015fetleri ve t\u00fcm a\u011f\u0131z bo\u015flu\u011fu \u00fczerinde kirli sar\u0131 zarla \u00f6rt\u00fcl\u00fc \u00fclserlerle kaplan\u0131r. Bu \u00fclserler ba\u015fka b\u00f6lgelerde(cilt, burun, vajen, makat gibi) de g\u00f6r\u00fclebilir. B\u00f6lgesel lenf bezi b\u00fcy\u00fckl\u00fckleri olabilir. Dalak b\u00fcy\u00fckl\u00fc\u011f\u00fc e\u015flik etmez.<\/p>\n
TANI<\/p>\n
Tan\u0131 hastanelerde kolayl\u0131kla ve d\u00fczenli yapt\u0131r\u0131labilen bir test olan tam kan say\u0131m\u0131 ile konulur. Kanda beyaz k\u00fcre-akyuvar say\u0131s\u0131 (l\u00f6kosit) 1000\/mm3 alt\u0131ndad\u0131r. N\u00f6trofiller(par\u00e7al\u0131 akyuvar) ya hi\u00e7 g\u00f6r\u00fclmez ya da %1-2 dir. Bu h\u00fccrelerin g\u00f6revi v\u00fccudu enfeksiyonlardan korumakt\u0131r. Beyaz k\u00fcrelerin \u00e7o\u011funu lenfositler olu\u015fturur. Agran\u00fclositozlu hastalarda kans\u0131zl\u0131k(anemi) ve trombosit d\u00fc\u015f\u00fckl\u00fc\u011f\u00fc g\u00f6r\u00fclmez di\u011fer kan de\u011ferleri normaldir.\u00a0 Sedimentasyon h\u0131z\u0131 artm\u0131\u015ft\u0131r. Kemik ili\u011fi incelemesinde normal h\u00fccrelerle birlikte olgunla\u015fmas\u0131 durmu\u015f beyaz k\u00fcre \u00f6nc\u00fcl h\u00fccreleri g\u00f6r\u00fcl\u00fcr. Agran\u00fclositoz tan\u0131s\u0131 aplastik Anemi, l\u00f6semi gibi hastal\u0131klarla kar\u0131\u015fabilece\u011finden ay\u0131r\u0131c\u0131 tan\u0131 i\u00e7in kemik ili\u011fi \u00f6rneklemesi gerekir.<\/p>\n
TEDAV\u0130<\/p>\n
Antibiotiklerin bulunmas\u0131ndan \u00f6nce agran\u00fclositoz hastalar\u0131 t\u00fcm v\u00fccudu saran enfeksiyonlarla kaybedilirdi. G\u00fcn\u00fcm\u00fczde uygulanan yo\u011fun Antibiyotik tedavileri ile hastalar enfeksiyon ilerlemeden kurtulabilmektedir.\u00a0 Tedavide en \u00f6nemli olan hastal\u0131\u011fa sebep olan ilac\u0131n b\u0131rak\u0131lmas\u0131d\u0131r. E\u011fer enfeksiyon belirtileri yoksa kan say\u0131mlar\u0131 ile hasta takip edilir, ila\u00e7 vermekten sak\u0131n\u0131l\u0131r ve ate\u015f y\u00fckselmesine kar\u015f\u0131 dikkatli olunur.<\/p>\n
HAZIRLAYAN; Dr.Funda CERAN<\/p>\n","protected":false},"excerpt":{"rendered":"
\u0130mmunolojik mekanizmalarla olu\u015fan ilaca ba\u011fl\u0131 n\u00f6tropenilerin en a\u011f\u0131r \u015fekli agran\u00fclositozdur. \u0130leri derecede n\u00f6tropeni, y\u00fcksek ate\u015f, nekrozlu anjinle seyreden ve yayg\u0131n enfeksiyonla(sepsis) sonlanan bir hastal\u0131kt\u0131r. \u00c7e\u015fitli ila\u00e7lar(epilepsi ila\u00e7lar\u0131, tiroid ila\u00e7ar\u0131, baz\u0131 sakinle\u015ftirici ila\u00e7lar gibi) sebep olabilir. \u0130la\u00e7lar farkl\u0131 \u015fekillerde agran\u00fclositoz meydana getirebilir. Bunlardan biri ila\u00e7lar\u0131n veya onun y\u0131k\u0131m\u0131 s\u0131ras\u0131nda olu\u015fan \u00fcr\u00fcnlerin do\u011frudan kemik ili\u011fi ortam\u0131n\u0131 veya Akyuvar \u00f6nc\u00fcl h\u00fccrelerine zarar vermesidir.[Devam\u0131n\u0131 Oku…]<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[22524],"tags":[23336,23325,23331,23335,23328],"_links":{"self":[{"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/posts\/13288"}],"collection":[{"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/comments?post=13288"}],"version-history":[{"count":0,"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/posts\/13288\/revisions"}],"wp:attachment":[{"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/media?parent=13288"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/categories?post=13288"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/tags?post=13288"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}