B\u00f6brek\u00fcst\u00fc bezi hayati \u00f6nemi olan hormonlar\u0131 salg\u0131layan bir endokrin organd\u0131r. Ad\u0131n\u0131 bulundu\u011fu yerden al\u0131r.<\/p>\n
B\u00f6breklerimizin \u00fcst\u00fcnde yer almas\u0131na ra\u011fmen b\u00f6breklerle ilgisi yoktur. Korteks dedi\u011fimiz d\u0131\u015f k\u0131sm\u0131 \u00fc\u00e7 b\u00f6l\u00fcmden olu\u015fur, i\u00e7 k\u0131sm\u0131 ise tek b\u00f6l\u00fcmd\u00fcr. Korteks de v\u00fccut i\u00e7in gerekli kortizon yap\u0131s\u0131ndaki Hormonlar \u00fcretilir. Bu hormonlar \u00fc\u00e7 gruptur: seks steroid hormonlar\u0131, mineralokortikoidler, glukokortikoidler. <\/p>\n
Addison hastal\u0131\u011f\u0131nda \u00f6zellikle bu Hormonlar\u0131n eksikli\u011fine ba\u011fl\u0131 belirtiler olur. Hastal\u0131\u011f\u0131 Thomas Addison tan\u0131mlad\u0131\u011f\u0131 i\u00e7in ismi verilmi\u015ftir.<\/p>\n
En s\u0131k g\u00f6r\u00fcld\u00fc\u011f\u00fc ya\u015flar 30- 40 ya\u015flar\u0131d\u0131r. kad\u0131nlarda daha fazla g\u00f6r\u00fcl\u00fcr. Hastal\u0131k ya b\u00f6brek\u00fcst\u00fc bezinin kendisine ait bozukluklar veya b\u00f6brek\u00fcst\u00fc bezini idare eden hipofiz bezinin yetersiz \u00e7al\u0131\u015fmas\u0131 sonucu ortaya \u00e7\u0131kar. B\u00f6brek\u00fcst\u00fc bezinin harabiyeti otoimmun sebepler, verem, mantar infeksiyonlar\u0131, meningokoksemi, lenfoma, amiloid veya demir birikimi ile olur.<\/p>\n
BEL\u0130RT\u0130LER\u0130<\/p>\n
Halsizlik, yorgunluk, i\u015ftahs\u0131zl\u0131k, zay\u0131flama ilk yak\u0131nmalard\u0131r. Bu \u015fikayetler pek \u00e7ok hastal\u0131kta da olan genel \u015fikayetler oldu\u011fu i\u00e7in \u00e7ok anlaml\u0131 olmayabilir. Bunlar d\u0131\u015f\u0131nda deri rengi koyula\u015fmas\u0131, a\u011f\u0131z i\u00e7inde ve v\u00fccuttaki kat yerlerinde koyu renk lekelenmeler, tansiyon d\u00fc\u015f\u00fckl\u00fc\u011f\u00fc, bulant\u0131, kusma, kab\u0131zl\u0131k, kar\u0131n a\u011fr\u0131s\u0131, \u015feker d\u00fc\u015f\u00fckl\u00fc\u011f\u00fc,\u00a0 ishal, kas eklem a\u011fr\u0131s\u0131, Tuzlu yeme arzusu, ciltte beyaz lekeler (vitiligo)\u00a0 g\u00f6r\u00fcl\u00fcr. Uzun s\u00fcren durumlarda psikolojik bozukluklar da g\u00f6r\u00fclebilir. Bunlar haf\u0131za bozuklu\u011fu, bilin\u00e7 bulan\u0131klar\u0131, Depresyon \u015feklinde olabilir.\u00a0 Androjen yetersizli\u011fi erkekte belirgin de\u011filken kad\u0131nda kas\u0131k ve koltukalt\u0131 k\u0131llarda azalma, adet kanamas\u0131 olmamas\u0131na,\u00a0 cinsel istek azalmas\u0131na sebep olur.<\/p>\n
TANI<\/p>\n
Tan\u0131s\u0131 i\u00e7in hastal\u0131\u011f\u0131 mutlaka akla getirmek gerekir. Hastal\u0131k yava\u015f ve sinsi geli\u015fti\u011fi i\u00e7in yak\u0131nmalar hastal\u0131k ilerledik\u00e7e daha belirgin hale gelir. Tan\u0131da bezin salg\u0131lamas\u0131 gereken hormonlar\u0131n eksikli\u011fi ve bu hormonlar\u0131n eksikli\u011finin yol a\u00e7t\u0131\u011f\u0131 laboratuar sonu\u00e7lar\u0131n\u0131n saptanmas\u0131 gerekir. Hastal\u0131\u011fa yol a\u00e7an sebepleri belirlemek i\u00e7in ultrason, bilgisayarl\u0131 tomografi (BT) ve manyetik rezonans g\u00f6r\u00fcnt\u00fcleme (MR) gibi g\u00f6r\u00fcnt\u00fcleme tetkikleri kullan\u0131l\u0131r. Ayr\u0131ca tan\u0131y\u0131 do\u011frulamak i\u00e7in hormonal uyar\u0131 ve bask\u0131lama testleri de yap\u0131l\u0131r.<\/p>\n
TEDAV\u0130<\/p>\n
Hastal\u0131k tan\u0131s\u0131 konulduktan sonra derhal eksik hormonlar\u0131n yerine konulmas\u0131 tedavisine (hormon replasman tedavisi) ba\u015flanmal\u0131d\u0131r. Hormonlar\u0131n ayar\u0131 ki\u015fiden ki\u015fiye farkl\u0131l\u0131k g\u00f6sterdi\u011fi i\u00e7in tedavi bireysel olmal\u0131 ve hastan\u0131n yak\u0131n takibi \u00f6nemlidir. Addison hastal\u0131\u011f\u0131 tan\u0131s\u0131 alan ki\u015fi \u00fczerinde mutlaka Addison hastas\u0131 oldu\u011funa dair bir kart veya belge ta\u015f\u0131mal\u0131d\u0131r. Bu belgeyi veya kart\u0131 daha sonra ba\u015fka nedenlerle de gidebilece\u011fi doktor dahil, t\u00fcm Sa\u011fl\u0131k ekibine g\u00f6stermelidir. \u00c7\u00fcnk\u00fc ba\u015fka hastal\u0131klara yakalanmas\u0131 durumunda veya cerrahi giri\u015fim gibi olaylar gerektiren durumlarda kulland\u0131\u011f\u0131 Hormon dozunun artt\u0131r\u0131lmas\u0131 gereklidir. Yine bu hastalara cerrahi m\u00fcdahale gerekirse hasta hormon ve s\u0131v\u0131- elektrolit y\u00f6n\u00fcnden dikkatli ve \u00f6zel olarak haz\u0131rlanmal\u0131d\u0131r.<\/p>\n
HAZIRLAYAN: Dr. Pelin T\u00dcT\u00dcNC\u00dcO\u011eLU, Prof. Dr. Mitat BAH\u00c7EC\u0130<\/p>\n","protected":false},"excerpt":{"rendered":"
B\u00f6brek\u00fcst\u00fc bezi hayati \u00f6nemi olan hormonlar\u0131 salg\u0131layan bir endokrin organd\u0131r. Ad\u0131n\u0131 bulundu\u011fu yerden al\u0131r. B\u00f6breklerimizin \u00fcst\u00fcnde yer almas\u0131na ra\u011fmen b\u00f6breklerle ilgisi yoktur. Korteks dedi\u011fimiz d\u0131\u015f k\u0131sm\u0131 \u00fc\u00e7 b\u00f6l\u00fcmden olu\u015fur, i\u00e7 k\u0131sm\u0131 ise tek b\u00f6l\u00fcmd\u00fcr. Korteks de v\u00fccut i\u00e7in gerekli kortizon yap\u0131s\u0131ndaki Hormonlar \u00fcretilir. Bu hormonlar \u00fc\u00e7 gruptur: seks steroid hormonlar\u0131, mineralokortikoidler, glukokortikoidler. Addison hastal\u0131\u011f\u0131nda \u00f6zellikle bu Hormonlar\u0131n eksikli\u011fine ba\u011fl\u0131 belirtiler[Devam\u0131n\u0131 Oku…]<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[22524],"tags":[23353,23355],"_links":{"self":[{"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/posts\/13296"}],"collection":[{"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/comments?post=13296"}],"version-history":[{"count":0,"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/posts\/13296\/revisions"}],"wp:attachment":[{"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/media?parent=13296"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/categories?post=13296"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/tags?post=13296"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}