ABD\u2019li bilim adamlar\u0131, T\u00fcrkiye\u2019de de kullan\u0131lan \u015feker hastal\u0131\u011f\u0131 (diyabet tip 2) ila\u00e7lar\u0131ndan \u201cAvandia\u201d ile \u201cActos\u201dun kalp yetersizli\u011fi ve kalp krizine neden oldu\u011funu ileri s\u00fcrd\u00fc. ABD, ila\u00e7lara k\u0131s\u0131tlama getirmeden \u00f6nce ba\u011f\u0131ms\u0131z ara\u015ft\u0131rmac\u0131lardan ikinci bir test istedi. \u00dcretici \u0130ngiliz Glaxo Smith Kline \u015firketi ise \u201cKalp krizine neden oldu\u011fu y\u00f6n\u00fcnde kesin kan\u0131t yok, prospekt\u00fcs\u00fcnde zaten kalp uyar\u0131s\u0131 var\u201d a\u00e7\u0131klamas\u0131n\u0131 yapt\u0131.Amerika ve Avrupa ba\u015fta olmak \u00fczere d\u00fcnyan\u0131n bir\u00e7ok \u00fclkesinde kullan\u0131lan ve piyasada \u201cAvandia\u201d ya da \u201cAvendamet\u201d ad\u0131yla sat\u0131lan \u015feker hastal\u0131\u011f\u0131 ilac\u0131 \u00fczerine ABD\u2019de yap\u0131lan ara\u015ft\u0131rma, kayg\u0131 verici sonu\u00e7lar ortaya \u0131kard\u0131. Ara\u015ft\u0131rman\u0131n sonu\u00e7lar\u0131, New England Journal of Medicine adl\u0131 derginin may\u0131s say\u0131s\u0131nda yay\u0131nlad\u0131.Gen\u00e7ler i\u00e7in de risk s\u00f6zkonusu78 bin \u015feker hastas\u0131 \u00fczerinde yap\u0131lan ara\u015ft\u0131rma, 1999\u2032dan bu yana piyasada bulunan \u0130ngiliz Glaxo Smith Kline \u015firketinin \u00fcretti\u011fi \u201cAvandia\u201d adl\u0131 ila\u00e7 ile Japon Takeda Farmakoloji \u015firketinin \u00fcretti\u011fi \u201cActos\u201d adl\u0131 ilac\u0131n kalp yetersizli\u011fini 2 kat, kalp krizi riskini ise, y\u00fczde 43 oran\u0131nda art\u0131rd\u0131\u011f\u0131n\u0131 ortaya koydu.Ge\u00e7en y\u0131l sadece ABD\u2019de 2 milyar dolarl\u0131k \u201cAvandia\u201d satan Glaxo Smith Kline, ilac\u0131n prospekt\u00fcs\u00fcnde uyar\u0131 bulundu\u011funu a\u00e7\u0131klad\u0131. Ancak North Carolina Wake Forest \u00dcniversitesi\u2019nden Prof. Sonal Singh, \u201cGe\u00e7mi\u015fte kalp riski bulunmayan, hatta gen\u00e7 ya\u015ftaki hastalarda bile kalp krizi riskini art\u0131rd\u0131\u201d diyerek firmay\u0131 yalanlad\u0131.Kutuya yaz\u0131lmas\u0131 gerekirdiAmerikan \u0130la\u00e7 ve G\u0131da Dairesi FDA, Glaxo Smith Kline\u2019\u0131n ge\u00e7ti\u011fimiz aylarda, baz\u0131 \u00fcr\u00fcnlerinin prospekt\u00fcs\u00fcndeki kalp riski uyar\u0131s\u0131n\u0131 g\u00fcncellemek istedi\u011fini, ancak bu denli \u00f6nemli bir uyar\u0131n\u0131n kapakta ve siyah kutu i\u00e7ine yaz\u0131lmas\u0131 gerekti\u011fi i\u00e7in talebin reddedildi\u011fini duyurdu. FDA, \u201cAvandia\u201d adl\u0131 ilaca y\u00f6nelik k\u0131s\u0131tlama karar\u0131 almadan \u00f6nce ila\u00e7la ilgili ba\u011f\u0131ms\u0131z bilimadamlar\u0131 gruplar\u0131ndan da ara\u015ft\u0131rma talebinde bulundu. Kurum ayr\u0131ca, Takeda \u015firketinin Actos, ve Merck & Co \u015firketinin de \u201cJanuvia\u201d adl\u0131 ila\u00e7lar\u0131n\u0131n da incelenmesini istedi.T\u00fcrkiye\u2019de de kullan\u0131l\u0131yorAvandia, Glaxo Smith Kline (GSK) ila\u00e7 \u015firketinin bir \u00fcr\u00fcn\u00fc ve T\u00fcrkiye\u2019de ayn\u0131 isimle sat\u0131\u015f\u0131 devam ediyor. Actos ise Lilly\u2019nin bir \u00fcr\u00fcn\u00fc, ancak T\u00fcrkiye\u2019de bu isimle mevcut de\u011fil. Bilim \u0130la\u00e7 taraf\u0131ndan \u00fcretilen jeneri\u011fi \u201cGlifix\u201d var. Jenerik ila\u00e7lar ve as\u0131llar\u0131nda etken Maddeleri ayn\u0131 oldu\u011fundan, bu ila\u00e7lar\u0131n her ikisinin de T\u00fcrkiye\u2019de eczanelerde sat\u0131ld\u0131\u011f\u0131n\u0131 s\u00f6ylemek m\u00fcmk\u00fcn. \u015eimdiye kadar herhangi bir toplatma karar\u0131 al\u0131nmad\u0131.<\/p>\n","protected":false},"excerpt":{"rendered":"
ABD\u2019li bilim adamlar\u0131, T\u00fcrkiye\u2019de de kullan\u0131lan \u015feker hastal\u0131\u011f\u0131 (diyabet tip 2) ila\u00e7lar\u0131ndan \u201cAvandia\u201d ile \u201cActos\u201dun kalp yetersizli\u011fi ve kalp krizine neden oldu\u011funu ileri s\u00fcrd\u00fc. ABD, ila\u00e7lara k\u0131s\u0131tlama getirmeden \u00f6nce ba\u011f\u0131ms\u0131z ara\u015ft\u0131rmac\u0131lardan ikinci bir test istedi. \u00dcretici \u0130ngiliz Glaxo Smith Kline \u015firketi ise \u201cKalp krizine neden oldu\u011fu y\u00f6n\u00fcnde kesin kan\u0131t yok, prospekt\u00fcs\u00fcnde zaten kalp uyar\u0131s\u0131 var\u201d a\u00e7\u0131klamas\u0131n\u0131 yapt\u0131.Amerika ve Avrupa ba\u015fta[Devam\u0131n\u0131 Oku…]<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[22524],"tags":[27303,29215,29213],"_links":{"self":[{"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/posts\/15386"}],"collection":[{"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/comments?post=15386"}],"version-history":[{"count":0,"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/posts\/15386\/revisions"}],"wp:attachment":[{"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/media?parent=15386"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/categories?post=15386"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gncz.net\/index.php\/wp-json\/wp\/v2\/tags?post=15386"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}